Taste receptor type 2 member 8 (TAS2R8)
Homo sapiens — UniProt Q9NYW2
Data last refreshed: (UniProt release unknown)
Key facts
Taste receptor type 2 member 8 (TAS2R8) is a protein from Homo sapiens identified by UniProt accession Q9NYW2, 309 residues long. MolForge cross-references it against 1 known binders and 11 disease associations.
- UniProt accession: Q9NYW2; gene symbol TAS2R8.
- Organism: Homo sapiens.
- Length: 309 amino acids.
- Top disease associations (Open Targets): ovarian cancer, breast adenocarcinoma and squamous cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Taste receptor type 2 member 8 |
|---|---|
| UniProt accession | Q9NYW2 |
| Gene | TAS2R8 |
| Organism | Homo sapiens |
| Length | 309 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.16
- squamous cell lung carcinoma · score 0.13
- head and neck squamous cell carcinoma · score 0.13
- gastric adenocarcinoma · score 0.10
- neoplasm · score 0.02
- neuroblastoma · score 0.01
- cancer · score 0.01
- papillary thyroid carcinoma · score 0.00
- oral squamous cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYW2-F1 | alphafold | PREDICTED | 81.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYW2.
Amino-acid sequence (309 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TAS2R8?
The strongest Open Targets associations for TAS2R8 are ovarian cancer, breast adenocarcinoma, squamous cell lung carcinoma, head and neck squamous cell carcinoma and gastric adenocarcinoma.
How long is the TAS2R8 protein?
The Homo sapiens TAS2R8 protein (UniProt Q9NYW2) is 309 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYW2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYW2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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