Taste receptor type 2 member 4 (TAS2R4)
Homo sapiens — UniProt Q9NYW5
Data last refreshed: (UniProt release unknown)
Key facts
Taste receptor type 2 member 4 (TAS2R4) is a protein from Homo sapiens identified by UniProt accession Q9NYW5, 299 residues long. MolForge cross-references it against 2 known binders and 24 disease associations.
- UniProt accession: Q9NYW5; gene symbol TAS2R4.
- Organism: Homo sapiens.
- Length: 299 amino acids.
- Approved drugs acting on it (DrugCentral): Azithromycin.
- Top disease associations (Open Targets): glioblastoma multiforme, squamous cell lung carcinoma and gastric adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Taste receptor type 2 member 4 |
|---|---|
| UniProt accession | Q9NYW5 |
| Gene | TAS2R4 |
| Organism | Homo sapiens |
| Length | 299 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (24)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.22
- squamous cell lung carcinoma · score 0.13
- gastric adenocarcinoma · score 0.10
- low grade glioma · score 0.10
- sensory perception of bitter taste · score 0.07
- type 2 diabetes mellitus · score 0.05
- venous thromboembolism · score 0.05
- neoplasm · score 0.01
- breast cancer · score 0.01
- head and neck squamous cell carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYW5-F1 | alphafold | PREDICTED | 84.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYW5.
Amino-acid sequence (299 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target TAS2R4?
DrugCentral lists 1 approved drug whose mechanism of action is TAS2R4: Azithromycin.
Which diseases are associated with TAS2R4?
The strongest Open Targets associations for TAS2R4 are glioblastoma multiforme, squamous cell lung carcinoma, gastric adenocarcinoma, low grade glioma and sensory perception of bitter taste.
How long is the TAS2R4 protein?
The Homo sapiens TAS2R4 protein (UniProt Q9NYW5) is 299 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYW5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYW5 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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