Serine/threonine-protein kinase PLK2 (PLK2)
Homo sapiens — UniProt Q9NYY3
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase PLK2 (PLK2) is a protein from Homo sapiens identified by UniProt accession Q9NYY3, 685 residues long. MolForge cross-references it against 5 known binders and 174 disease associations.
- UniProt accession: Q9NYY3; gene symbol PLK2.
- Organism: Homo sapiens.
- Length: 685 amino acids.
- Top disease associations (Open Targets): neuroinflammatory disorder, diastolic blood pressure and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase PLK2 |
|---|---|
| UniProt accession | Q9NYY3 |
| Gene | PLK2 |
| Organism | Homo sapiens |
| Length | 685 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (174)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.44
- diastolic blood pressure · score 0.42
- lymphocyte count · score 0.40
- self reported educational attainment · score 0.39
- systolic blood pressure · score 0.39
- leukocyte count · score 0.37
- monocyte count · score 0.36
- hereditary breast ovarian cancer syndrome · score 0.34
- Hereditary breast and ovarian cancer syndrome · score 0.34
- mathematical ability · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYY3-F1 | alphafold | PREDICTED | 75.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYY3.
Amino-acid sequence (685 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLK2?
The strongest Open Targets associations for PLK2 are neuroinflammatory disorder, diastolic blood pressure, lymphocyte count, self reported educational attainment and systolic blood pressure.
How long is the PLK2 protein?
The Homo sapiens PLK2 protein (UniProt Q9NYY3) is 685 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYY3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYY3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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