FAST kinase domain-containing protein 2, mitochondrial (FASTKD2)
Homo sapiens — UniProt Q9NYY8
Data last refreshed: (UniProt release unknown)
Key facts
FAST kinase domain-containing protein 2, mitochondrial (FASTKD2) is a protein from Homo sapiens identified by UniProt accession Q9NYY8, 710 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q9NYY8; gene symbol FASTKD2.
- Organism: Homo sapiens.
- Length: 710 amino acids.
- Top disease associations (Open Targets): combined oxidative phosphorylation deficiency 44, mitochondrial complex IV deficiency, nuclear type 22 and leigh syndrome due to mitochondrial complex iv deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FAST kinase domain-containing protein 2, mitochondrial |
|---|---|
| UniProt accession | Q9NYY8 |
| Gene | FASTKD2 |
| Organism | Homo sapiens |
| Length | 710 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 44 · score 0.73
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.49
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.49
- Leigh syndrome · score 0.45
- mitochondrial disease · score 0.37
- FASTKD2-related infantile mitochondrial encephalomyopathy · score 0.37
- genetic disorder · score 0.19
- episodic memory · score 0.19
- insomnia · score 0.18
- total blood protein measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYY8-F1 | alphafold | PREDICTED | 75.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYY8.
Amino-acid sequence (710 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FASTKD2?
The strongest Open Targets associations for FASTKD2 are combined oxidative phosphorylation deficiency 44, mitochondrial complex IV deficiency, nuclear type 22, leigh syndrome due to mitochondrial complex iv deficiency, Leigh syndrome and mitochondrial disease.
How long is the FASTKD2 protein?
The Homo sapiens FASTKD2 protein (UniProt Q9NYY8) is 710 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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