Sialic acid-binding Ig-like lectin 8 (SIGLEC8)
Homo sapiens — UniProt Q9NYZ4
Data last refreshed: (UniProt release unknown)
Key facts
Sialic acid-binding Ig-like lectin 8 (SIGLEC8) is a protein from Homo sapiens identified by UniProt accession Q9NYZ4, 499 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q9NYZ4; gene symbol SIGLEC8.
- Organism: Homo sapiens.
- Length: 499 amino acids.
- Top disease associations (Open Targets): eosinophilic gastroenteritis, duodenitis and eosinophilic esophagitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sialic acid-binding Ig-like lectin 8 |
|---|---|
| UniProt accession | Q9NYZ4 |
| Gene | SIGLEC8 |
| Organism | Homo sapiens |
| Length | 499 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- eosinophilic gastroenteritis · score 0.26
- duodenitis · score 0.26
- eosinophilic esophagitis · score 0.08
- neutrophil immunodeficiency syndrome · score 0.08
- atopic eczema · score 0.07
- chronic idiopathic urticaria · score 0.07
- urticaria · score 0.07
- breast cancer · score 0.06
- Recurrent infection due to specific granule deficiency · score 0.06
- isolated agammaglobulinemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYZ4-F1 | alphafold | PREDICTED | 73.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYZ4.
Amino-acid sequence (499 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIGLEC8?
The strongest Open Targets associations for SIGLEC8 are eosinophilic gastroenteritis, duodenitis, eosinophilic esophagitis, neutrophil immunodeficiency syndrome and atopic eczema.
How long is the SIGLEC8 protein?
The Homo sapiens SIGLEC8 protein (UniProt Q9NYZ4) is 499 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYZ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYZ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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