Group 3 secretory phospholipase A2 (PLA2G3)
Homo sapiens — UniProt Q9NZ20
Data last refreshed: (UniProt release unknown)
Key facts
Group 3 secretory phospholipase A2 (PLA2G3) is a protein from Homo sapiens identified by UniProt accession Q9NZ20, 509 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.
- UniProt accession: Q9NZ20; gene symbol PLA2G3.
- Organism: Homo sapiens.
- Length: 509 amino acids.
- Top disease associations (Open Targets): vitamin D measurement, appendicular lean mass and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Group 3 secretory phospholipase A2 |
|---|---|
| UniProt accession | Q9NZ20 |
| Gene | PLA2G3 |
| Organism | Homo sapiens |
| Length | 509 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (158)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.41
- appendicular lean mass · score 0.20
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- drug use measurement · score 0.16
- gut microbiome measurement · score 0.14
- diet measurement · score 0.11
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 65 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZ20-F1 | alphafold | PREDICTED | 70.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZ20.
Amino-acid sequence (509 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLA2G3?
The strongest Open Targets associations for PLA2G3 are vitamin D measurement, appendicular lean mass, glioblastoma multiforme, breast adenocarcinoma and drug use measurement.
How long is the PLA2G3 protein?
The Homo sapiens PLA2G3 protein (UniProt Q9NZ20) is 509 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZ20 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZ20 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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