Gamma-secretase subunit PEN-2 (PSENEN)
Homo sapiens — UniProt Q9NZ42
Data last refreshed: (UniProt release unknown)
Key facts
Gamma-secretase subunit PEN-2 (PSENEN) is a protein from Homo sapiens identified by UniProt accession Q9NZ42, 101 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q9NZ42; gene symbol PSENEN.
- Organism: Homo sapiens.
- Length: 101 amino acids.
- Top disease associations (Open Targets): hidradenitis suppurativa, neurodegenerative disease and Dowling-Degos disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gamma-secretase subunit PEN-2 |
|---|---|
| UniProt accession | Q9NZ42 |
| Gene | PSENEN |
| Organism | Homo sapiens |
| Length | 101 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- hidradenitis suppurativa · score 0.68
- neurodegenerative disease · score 0.53
- Dowling-Degos disease · score 0.46
- Alzheimer disease · score 0.39
- Dementia · score 0.32
- Desmoid-type fibromatosis · score 0.29
- breast adenocarcinoma · score 0.25
- lung adenocarcinoma · score 0.19
- Red cell distribution width · score 0.19
- ovarian cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZ42-F1 | alphafold | PREDICTED | 92.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZ42.
Amino-acid sequence (101 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PSENEN?
The strongest Open Targets associations for PSENEN are hidradenitis suppurativa, neurodegenerative disease, Dowling-Degos disease, Alzheimer disease and Dementia.
How long is the PSENEN protein?
The Homo sapiens PSENEN protein (UniProt Q9NZ42) is 101 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZ42 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZ42 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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