Neuroligin-3 (NLGN3)
Homo sapiens — UniProt Q9NZ94
Data last refreshed: (UniProt release unknown)
Key facts
Neuroligin-3 (NLGN3) is a protein from Homo sapiens identified by UniProt accession Q9NZ94, 848 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.
- UniProt accession: Q9NZ94; gene symbol NLGN3.
- Organism: Homo sapiens.
- Length: 848 amino acids.
- Top disease associations (Open Targets): autism, autism spectrum disorder and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuroligin-3 |
|---|---|
| UniProt accession | Q9NZ94 |
| Gene | NLGN3 |
| Organism | Homo sapiens |
| Length | 848 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (170)
Diseases linked to this target (Open Targets).
- autism · score 0.60
- autism spectrum disorder · score 0.57
- genetic disorder · score 0.45
- Intellectual disability · score 0.42
- Asperger syndrome · score 0.39
- neurodegenerative disease · score 0.37
- Autistic behavior · score 0.34
- hypogonadotropic hypogonadism · score 0.34
- X-linked complex neurodevelopmental disorder · score 0.18
- complex neurodevelopmental disorder · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZ94-F1 | alphafold | PREDICTED | 76.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZ94.
Amino-acid sequence (848 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NLGN3?
The strongest Open Targets associations for NLGN3 are autism, autism spectrum disorder, genetic disorder, Intellectual disability and Asperger syndrome.
How long is the NLGN3 protein?
The Homo sapiens NLGN3 protein (UniProt Q9NZ94) is 848 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZ94 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZ94 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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