Chloride intracellular channel protein 5 (CLIC5)
Homo sapiens — UniProt Q9NZA1
Data last refreshed: (UniProt release unknown)
Key facts
Chloride intracellular channel protein 5 (CLIC5) is a protein from Homo sapiens identified by UniProt accession Q9NZA1, 410 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.
- UniProt accession: Q9NZA1; gene symbol CLIC5.
- Organism: Homo sapiens.
- Length: 410 amino acids.
- Top disease associations (Open Targets): hearing loss, autosomal recessive, deafness and hair color.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Chloride intracellular channel protein 5 |
|---|---|
| UniProt accession | Q9NZA1 |
| Gene | CLIC5 |
| Organism | Homo sapiens |
| Length | 410 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (109)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal recessive · score 0.51
- deafness · score 0.43
- hair color · score 0.39
- heel bone mineral density · score 0.39
- intraocular pressure measurement · score 0.32
- hair colour measurement · score 0.30
- brain measurement · score 0.28
- mean corpuscular volume · score 0.23
- hair shape measurement · score 0.23
- balding measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZA1-F1 | alphafold | PREDICTED | 67.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZA1.
Amino-acid sequence (410 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLIC5?
The strongest Open Targets associations for CLIC5 are hearing loss, autosomal recessive, deafness, hair color, heel bone mineral density and intraocular pressure measurement.
How long is the CLIC5 protein?
The Homo sapiens CLIC5 protein (UniProt Q9NZA1) is 410 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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