Glycerophosphodiester phosphodiesterase 1 (GDE1)

About Glycerophosphodiester phosphodiesterase 1

Glycerophosphodiester phosphodiesterase 1 (GDE1) is a protein from Homo sapiens identified by UniProt accession Q9NZC3, 331 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Glycerophosphodiester phosphodiesterase 1
UniProt accession	Q9NZC3
Gene	GDE1
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

cortical surface area measurement · score 0.11
glycogen storage disease due to lactate dehydrogenase H-subunit deficiency · score 0.07
alcohol sensitivity, acute · score 0.05
platelet crit · score 0.05
acatalasia · score 0.05
Brugada syndrome · score 0.04
dehydrated hereditary stomatocytosis · score 0.04
Platelet-activating factor acetylhydrolase deficiency · score 0.04
Combined hyperlipidemia · score 0.04
arrhythmogenic right ventricular dysplasia 10 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NZC3-F1	alphafold	PREDICTED	94.54	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZC3.

Amino-acid sequence (331 residues)

MWLWEDQGGL LGPFSFLLLV LLLVTRSPVN ACLLTGSLFV LLRVFSFEPV PSCRALQVLK PRDRISAIAH RGGSHDAPEN TLAAIRQAAK NGATGVELDI EFTSDGIPVL MHDNTVDRTT DGTGRLCDLT FEQIRKLNPA ANHRLRNDFP DEKIPTLREA VAECLNHNLT IFFDVKGHAH KATEALKKMY MEFPQLYNNS VVCSFLPEVI YKMRQTDRDV ITALTHRPWS LSHTGDGKPR YDTFWKHFIF VMMDILLDWS MHNILWYLCG ISAFLMQKDF VSPAYLKKWS AKGIQVVGWT VNTFDEKSYY ESHLGSSYIT DSMVEDCEPH F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards