WW domain-containing oxidoreductase (WWOX)
Homo sapiens — UniProt Q9NZC7
Data last refreshed: (UniProt release unknown)
Key facts
WW domain-containing oxidoreductase (WWOX) is a protein from Homo sapiens identified by UniProt accession Q9NZC7, 414 residues long. MolForge cross-references it against 0 known binders and 542 disease associations.
- UniProt accession: Q9NZC7; gene symbol WWOX.
- Organism: Homo sapiens.
- Length: 414 amino acids.
- Top disease associations (Open Targets): autosomal recessive spinocerebellar ataxia 12, developmental and epileptic encephalopathy, 28 and developmental and epileptic encephalopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WW domain-containing oxidoreductase |
|---|---|
| UniProt accession | Q9NZC7 |
| Gene | WWOX |
| Organism | Homo sapiens |
| Length | 414 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (542)
Diseases linked to this target (Open Targets).
- autosomal recessive spinocerebellar ataxia 12 · score 0.80
- developmental and epileptic encephalopathy, 28 · score 0.76
- developmental and epileptic encephalopathy · score 0.67
- undetermined early-onset epileptic encephalopathy · score 0.66
- esophageal squamous cell carcinoma · score 0.64
- West syndrome · score 0.55
- developmental and epileptic encephalopathy, 1 · score 0.55
- infantile epileptic-dyskinetic encephalopathy · score 0.55
- Spasticity - intellectual disability - X-linked epilepsy · score 0.55
- vital capacity · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZC7-F1 | alphafold | PREDICTED | 85.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZC7.
Amino-acid sequence (414 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WWOX?
The strongest Open Targets associations for WWOX are autosomal recessive spinocerebellar ataxia 12, developmental and epileptic encephalopathy, 28, developmental and epileptic encephalopathy, undetermined early-onset epileptic encephalopathy and esophageal squamous cell carcinoma.
How long is the WWOX protein?
The Homo sapiens WWOX protein (UniProt Q9NZC7) is 414 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZC7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZC7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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