SNF2 related chromatin remodeling annealing helicase 1 (SMARCAL1)
Homo sapiens — UniProt Q9NZC9
Data last refreshed: (UniProt release unknown)
Key facts
SNF2 related chromatin remodeling annealing helicase 1 (SMARCAL1) is a protein from Homo sapiens identified by UniProt accession Q9NZC9, 954 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.
- UniProt accession: Q9NZC9; gene symbol SMARCAL1.
- Organism: Homo sapiens.
- Length: 954 amino acids.
- Top disease associations (Open Targets): Schimke immuno-osseous dysplasia, focal segmental glomerulosclerosis and steroid-resistant nephrotic syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SNF2 related chromatin remodeling annealing helicase 1 |
|---|---|
| UniProt accession | Q9NZC9 |
| Gene | SMARCAL1 |
| Organism | Homo sapiens |
| Length | 954 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- Schimke immuno-osseous dysplasia · score 0.84
- focal segmental glomerulosclerosis · score 0.46
- steroid-resistant nephrotic syndrome · score 0.43
- Microcephaly · score 0.43
- Short stature · score 0.43
- Disproportionate short-trunk short stature · score 0.43
- Decreased body weight · score 0.43
- Small for gestational age · score 0.43
- Primary microcephaly · score 0.43
- familial atrioventricular septal defect · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZC9-F1 | alphafold | PREDICTED | 69.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZC9.
Amino-acid sequence (954 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMARCAL1?
The strongest Open Targets associations for SMARCAL1 are Schimke immuno-osseous dysplasia, focal segmental glomerulosclerosis, steroid-resistant nephrotic syndrome, Microcephaly and Short stature.
How long is the SMARCAL1 protein?
The Homo sapiens SMARCAL1 protein (UniProt Q9NZC9) is 954 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZC9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZC9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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