G-protein coupled receptor family C group 5 member D (GPRC5D)
Homo sapiens — UniProt Q9NZD1
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor family C group 5 member D (GPRC5D) is a protein from Homo sapiens identified by UniProt accession Q9NZD1, 345 residues long. MolForge cross-references it against 1 known binders and 34 disease associations.
- UniProt accession: Q9NZD1; gene symbol GPRC5D.
- Organism: Homo sapiens.
- Length: 345 amino acids.
- Approved drugs acting on it (DrugCentral): Talquetamab.
- Top disease associations (Open Targets): multiple myeloma, urate measurement and bone density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor family C group 5 member D |
|---|---|
| UniProt accession | Q9NZD1 |
| Gene | GPRC5D |
| Organism | Homo sapiens |
| Length | 345 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (34)
Diseases linked to this target (Open Targets).
- multiple myeloma · score 0.50
- urate measurement · score 0.22
- bone density · score 0.22
- mean corpuscular volume · score 0.10
- cutaneous melanoma · score 0.10
- mean corpuscular hemoglobin concentration · score 0.09
- mean reticulocyte volume · score 0.09
- erythrocyte count · score 0.09
- nevus count · score 0.09
- mean corpuscular hemoglobin · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZD1-F1 | alphafold | PREDICTED | 76.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZD1.
Amino-acid sequence (345 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target GPRC5D?
DrugCentral lists 1 approved drug whose mechanism of action is GPRC5D: Talquetamab.
Which diseases are associated with GPRC5D?
The strongest Open Targets associations for GPRC5D are multiple myeloma, urate measurement, bone density, mean corpuscular volume and cutaneous melanoma.
How long is the GPRC5D protein?
The Homo sapiens GPRC5D protein (UniProt Q9NZD1) is 345 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZD1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZD1 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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