Maspardin (SPG21)
Homo sapiens — UniProt Q9NZD8
Data last refreshed: (UniProt release unknown)
Key facts
Maspardin (SPG21) is a protein from Homo sapiens identified by UniProt accession Q9NZD8, 308 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q9NZD8; gene symbol SPG21.
- Organism: Homo sapiens.
- Length: 308 amino acids.
- Top disease associations (Open Targets): mast syndrome, hereditary sensory and autonomic neuropathy with spastic paraplegia and hereditary spastic paraplegia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Maspardin |
|---|---|
| UniProt accession | Q9NZD8 |
| Gene | SPG21 |
| Organism | Homo sapiens |
| Length | 308 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- mast syndrome · score 0.74
- hereditary sensory and autonomic neuropathy with spastic paraplegia · score 0.50
- hereditary spastic paraplegia · score 0.47
- body height · score 0.13
- hepatocellular carcinoma · score 0.03
- hypertrophic cardiomyopathy · score 0.02
- tarsal-carpal coalition syndrome · score 0.01
- neoplasm · score 0.00
- multiple myeloma · score 0.00
- Paraplegia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZD8-F1 | alphafold | PREDICTED | 92.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZD8.
Amino-acid sequence (308 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPG21?
The strongest Open Targets associations for SPG21 are mast syndrome, hereditary sensory and autonomic neuropathy with spastic paraplegia, hereditary spastic paraplegia, body height and hepatocellular carcinoma.
How long is the SPG21 protein?
The Homo sapiens SPG21 protein (UniProt Q9NZD8) is 308 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZD8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZD8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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