Large ribosomal subunit protein bL35m (MRPL35)
Homo sapiens — UniProt Q9NZE8
Data last refreshed: (UniProt release unknown)
Key facts
Large ribosomal subunit protein bL35m (MRPL35) is a protein from Homo sapiens identified by UniProt accession Q9NZE8, 188 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q9NZE8; gene symbol MRPL35.
- Organism: Homo sapiens.
- Length: 188 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large ribosomal subunit protein bL35m |
|---|---|
| UniProt accession | Q9NZE8 |
| Gene | MRPL35 |
| Organism | Homo sapiens |
| Length | 188 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Parkinson disease · score 0.36
- multiple sclerosis · score 0.36
- Alzheimer disease · score 0.36
- lysosomal storage disease · score 0.36
- systolic blood pressure · score 0.26
- reticulocyte count · score 0.18
- diastolic blood pressure · score 0.18
- non-small cell lung carcinoma · score 0.09
- gonorrhea · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZE8-F1 | alphafold | PREDICTED | 74.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZE8.
Amino-acid sequence (188 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRPL35?
The strongest Open Targets associations for MRPL35 are neurodegenerative disease, Parkinson disease, multiple sclerosis, Alzheimer disease and lysosomal storage disease.
How long is the MRPL35 protein?
The Homo sapiens MRPL35 protein (UniProt Q9NZE8) is 188 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZE8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZE8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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