Placenta-specific gene 8 protein (PLAC8)
Homo sapiens — UniProt Q9NZF1
Data last refreshed: (UniProt release unknown)
Key facts
Placenta-specific gene 8 protein (PLAC8) is a protein from Homo sapiens identified by UniProt accession Q9NZF1, 115 residues long. MolForge cross-references it against 0 known binders and 257 disease associations.
- UniProt accession: Q9NZF1; gene symbol PLAC8.
- Organism: Homo sapiens.
- Length: 115 amino acids.
- Top disease associations (Open Targets): monocyte count, monocyte percentage of leukocytes and visual perception measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Placenta-specific gene 8 protein |
|---|---|
| UniProt accession | Q9NZF1 |
| Gene | PLAC8 |
| Organism | Homo sapiens |
| Length | 115 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (257)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.22
- monocyte percentage of leukocytes · score 0.20
- visual perception measurement · score 0.15
- blood protein measurement · score 0.15
- systemic lupus erythematosus · score 0.15
- leukocyte count · score 0.14
- granulocyte percentage of myeloid white cells · score 0.13
- lymphocyte:monocyte ratio · score 0.11
- oral squamous cell carcinoma · score 0.08
- breast cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZF1-F1 | alphafold | PREDICTED | 88.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZF1.
Amino-acid sequence (115 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLAC8?
The strongest Open Targets associations for PLAC8 are monocyte count, monocyte percentage of leukocytes, visual perception measurement, blood protein measurement and systemic lupus erythematosus.
How long is the PLAC8 protein?
The Homo sapiens PLAC8 protein (UniProt Q9NZF1) is 115 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZF1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZF1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.