G-protein coupled receptor family C group 5 member B (GPRC5B)
Homo sapiens — UniProt Q9NZH0
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor family C group 5 member B (GPRC5B) is a protein from Homo sapiens identified by UniProt accession Q9NZH0, 403 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q9NZH0; gene symbol GPRC5B.
- Organism: Homo sapiens.
- Length: 403 amino acids.
- Top disease associations (Open Targets): body mass index, lean body mass and triglyceride measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor family C group 5 member B |
|---|---|
| UniProt accession | Q9NZH0 |
| Gene | GPRC5B |
| Organism | Homo sapiens |
| Length | 403 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- body mass index · score 0.47
- lean body mass · score 0.40
- triglyceride measurement · score 0.28
- total cholesterol measurement · score 0.27
- physical activity measurement · score 0.26
- appendicular lean mass · score 0.26
- platelet count · score 0.26
- whole body water mass · score 0.25
- obesity · score 0.25
- smoking behavior · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZH0-F1 | alphafold | PREDICTED | 74.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZH0.
Amino-acid sequence (403 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPRC5B?
The strongest Open Targets associations for GPRC5B are body mass index, lean body mass, triglyceride measurement, total cholesterol measurement and physical activity measurement.
How long is the GPRC5B protein?
The Homo sapiens GPRC5B protein (UniProt Q9NZH0) is 403 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZH0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZH0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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