Securin-2 (PTTG2)
Homo sapiens — UniProt Q9NZH5
Data last refreshed: (UniProt release unknown)
Key facts
Securin-2 (PTTG2) is a protein from Homo sapiens identified by UniProt accession Q9NZH5, 202 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q9NZH5; gene symbol PTTG2.
- Organism: Homo sapiens.
- Length: 202 amino acids.
- Top disease associations (Open Targets): eosinophil count, appendicular lean mass and neutrophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Securin-2 |
|---|---|
| UniProt accession | Q9NZH5 |
| Gene | PTTG2 |
| Organism | Homo sapiens |
| Length | 202 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.14
- appendicular lean mass · score 0.13
- neutrophil percentage of leukocytes · score 0.12
- lymphocyte count · score 0.12
- lymphocyte percentage of leukocytes · score 0.11
- lymphocyte:monocyte ratio · score 0.10
- monocyte count · score 0.10
- monocyte percentage of leukocytes · score 0.10
- cellulitis · score 0.09
- neutrophil-to-lymphocyte ratio · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZH5-F1 | alphafold | PREDICTED | 61.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZH5.
Amino-acid sequence (202 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTTG2?
The strongest Open Targets associations for PTTG2 are eosinophil count, appendicular lean mass, neutrophil percentage of leukocytes, lymphocyte count and lymphocyte percentage of leukocytes.
How long is the PTTG2 protein?
The Homo sapiens PTTG2 protein (UniProt Q9NZH5) is 202 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZH5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZH5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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