Interleukin-37 (IL37)
Homo sapiens — UniProt Q9NZH6
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-37 (IL37) is a protein from Homo sapiens identified by UniProt accession Q9NZH6, 218 residues long. MolForge cross-references it against 0 known binders and 558 disease associations.
- UniProt accession: Q9NZH6; gene symbol IL37.
- Organism: Homo sapiens.
- Length: 218 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, inflammatory bowel disease and interleukin-1 beta measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-37 |
|---|---|
| UniProt accession | Q9NZH6 |
| Gene | IL37 |
| Organism | Homo sapiens |
| Length | 218 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (558)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- inflammatory bowel disease · score 0.35
- interleukin-1 beta measurement · score 0.28
- Eczematoid dermatitis · score 0.23
- pericarditis · score 0.14
- C-reactive protein measurement · score 0.12
- neoplasm · score 0.12
- Rheumatoid arthritis · score 0.11
- hepatocellular carcinoma · score 0.11
- Systemic lupus erythematosus · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZH6-F1 | alphafold | PREDICTED | 81.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZH6.
Amino-acid sequence (218 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IL37?
The strongest Open Targets associations for IL37 are neurodegenerative disease, inflammatory bowel disease, interleukin-1 beta measurement, Eczematoid dermatitis and pericarditis.
How long is the IL37 protein?
The Homo sapiens IL37 protein (UniProt Q9NZH6) is 218 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZH6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZH6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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