Grainyhead-like protein 1 homolog (GRHL1)
Homo sapiens — UniProt Q9NZI5
Data last refreshed: (UniProt release unknown)
Key facts
Grainyhead-like protein 1 homolog (GRHL1) is a protein from Homo sapiens identified by UniProt accession Q9NZI5, 618 residues long. MolForge cross-references it against 0 known binders and 194 disease associations.
- UniProt accession: Q9NZI5; gene symbol GRHL1.
- Organism: Homo sapiens.
- Length: 618 amino acids.
- Top disease associations (Open Targets): prostate carcinoma, calcium measurement and breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Grainyhead-like protein 1 homolog |
|---|---|
| UniProt accession | Q9NZI5 |
| Gene | GRHL1 |
| Organism | Homo sapiens |
| Length | 618 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (194)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.42
- calcium measurement · score 0.35
- breast carcinoma · score 0.34
- blood urea nitrogen measurement · score 0.34
- serum urea measurement · score 0.30
- type 2 diabetes mellitus · score 0.27
- DNA methylation · score 0.12
- urate measurement · score 0.10
- hypotrichosis simplex · score 0.09
- non-small cell lung carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZI5-F1 | alphafold | PREDICTED | 67.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZI5.
Amino-acid sequence (618 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GRHL1?
The strongest Open Targets associations for GRHL1 are prostate carcinoma, calcium measurement, breast carcinoma, blood urea nitrogen measurement and serum urea measurement.
How long is the GRHL1 protein?
The Homo sapiens GRHL1 protein (UniProt Q9NZI5) is 618 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZI5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZI5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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