Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
Homo sapiens — UniProt Q9NZI8
Data last refreshed: (UniProt release unknown)
Key facts
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is a protein from Homo sapiens identified by UniProt accession Q9NZI8, 577 residues long. MolForge cross-references it against 0 known binders and 239 disease associations.
- UniProt accession: Q9NZI8; gene symbol IGF2BP1.
- Organism: Homo sapiens.
- Length: 577 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body fat percentage and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Insulin-like growth factor 2 mRNA-binding protein 1 |
|---|---|
| UniProt accession | Q9NZI8 |
| Gene | IGF2BP1 |
| Organism | Homo sapiens |
| Length | 577 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (239)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.57
- body fat percentage · score 0.44
- body mass index · score 0.44
- lean body mass · score 0.41
- cognitive function measurement · score 0.39
- type 2 diabetes mellitus · score 0.37
- alcohol use disorder measurement · score 0.36
- longitudinal alcohol consumption measurement · score 0.36
- fat body mass · score 0.36
- sex hormone-binding globulin measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZI8-F1 | alphafold | PREDICTED | 77.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZI8.
Amino-acid sequence (577 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IGF2BP1?
The strongest Open Targets associations for IGF2BP1 are neurodegenerative disease, body fat percentage, body mass index, lean body mass and cognitive function measurement.
How long is the IGF2BP1 protein?
The Homo sapiens IGF2BP1 protein (UniProt Q9NZI8) is 577 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZI8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZI8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.