Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Homo sapiens — UniProt Q9NZJ5
Data last refreshed: (UniProt release unknown)
Key facts
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) is a protein from Homo sapiens identified by UniProt accession Q9NZJ5, 1116 residues long. MolForge cross-references it against 0 known binders and 661 disease associations.
- UniProt accession: Q9NZJ5; gene symbol EIF2AK3.
- Organism: Homo sapiens.
- Length: 1116 amino acids.
- Top disease associations (Open Targets): Wolcott-Rallison syndrome, cancer and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Eukaryotic translation initiation factor 2-alpha kinase 3 |
|---|---|
| UniProt accession | Q9NZJ5 |
| Gene | EIF2AK3 |
| Organism | Homo sapiens |
| Length | 1116 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (661)
Diseases linked to this target (Open Targets).
- Wolcott-Rallison syndrome · score 0.80
- cancer · score 0.53
- neurodegenerative disease · score 0.47
- body height · score 0.38
- lean body mass · score 0.35
- Menkes disease · score 0.34
- chronotype measurement · score 0.30
- appendicular lean mass · score 0.30
- vital capacity · score 0.30
- progressive supranuclear palsy · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZJ5-F1 | alphafold | PREDICTED | 59.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZJ5.
Amino-acid sequence (1116 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EIF2AK3?
The strongest Open Targets associations for EIF2AK3 are Wolcott-Rallison syndrome, cancer, neurodegenerative disease, body height and lean body mass.
How long is the EIF2AK3 protein?
The Homo sapiens EIF2AK3 protein (UniProt Q9NZJ5) is 1116 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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