Diphosphoinositol polyphosphate phosphohydrolase 2 (NUDT4)
Homo sapiens — UniProt Q9NZJ9
Data last refreshed: (UniProt release unknown)
Key facts
Diphosphoinositol polyphosphate phosphohydrolase 2 (NUDT4) is a protein from Homo sapiens identified by UniProt accession Q9NZJ9, 180 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q9NZJ9; gene symbol NUDT4.
- Organism: Homo sapiens.
- Length: 180 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, mean corpuscular hemoglobin concentration and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Diphosphoinositol polyphosphate phosphohydrolase 2 |
|---|---|
| UniProt accession | Q9NZJ9 |
| Gene | NUDT4 |
| Organism | Homo sapiens |
| Length | 180 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.44
- mean corpuscular hemoglobin concentration · score 0.44
- reticulocyte count · score 0.43
- mean corpuscular hemoglobin · score 0.41
- Red cell distribution width · score 0.40
- sex hormone-binding globulin measurement · score 0.38
- reticulocyte measurement · score 0.35
- Immature Reticulocyte Fraction Measurement · score 0.30
- smoking status measurement · score 0.30
- hemoglobin A1 measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZJ9-F1 | alphafold | PREDICTED | 84.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZJ9.
Amino-acid sequence (180 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUDT4?
The strongest Open Targets associations for NUDT4 are mean corpuscular volume, mean corpuscular hemoglobin concentration, reticulocyte count, mean corpuscular hemoglobin and Red cell distribution width.
How long is the NUDT4 protein?
The Homo sapiens NUDT4 protein (UniProt Q9NZJ9) is 180 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZJ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZJ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.