Adenosine deaminase 2 (ADA2)
Homo sapiens — UniProt Q9NZK5
Data last refreshed: (UniProt release unknown)
Key facts
Adenosine deaminase 2 (ADA2) is a protein from Homo sapiens identified by UniProt accession Q9NZK5, 511 residues long. MolForge cross-references it against 0 known binders and 247 disease associations.
- UniProt accession: Q9NZK5; gene symbol ADA2.
- Organism: Homo sapiens.
- Length: 511 amino acids.
- Top disease associations (Open Targets): vasculitis due to ADA2 deficiency, Sneddon syndrome and polyarteritis nodosa, childhoood-onset.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adenosine deaminase 2 |
|---|---|
| UniProt accession | Q9NZK5 |
| Gene | ADA2 |
| Organism | Homo sapiens |
| Length | 511 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (247)
Diseases linked to this target (Open Targets).
- vasculitis due to ADA2 deficiency · score 0.81
- Sneddon syndrome · score 0.74
- polyarteritis nodosa, childhoood-onset · score 0.72
- Diamond-Blackfan anemia · score 0.60
- vasculitis · score 0.58
- autoinflammatory syndrome · score 0.51
- Behcet's syndrome · score 0.48
- deficiency of adenosine deaminase 2 · score 0.44
- blood protein measurement · score 0.39
- stroke · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZK5-F1 | alphafold | PREDICTED | 95.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZK5.
Amino-acid sequence (511 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADA2?
The strongest Open Targets associations for ADA2 are vasculitis due to ADA2 deficiency, Sneddon syndrome, polyarteritis nodosa, childhoood-onset, Diamond-Blackfan anemia and vasculitis.
How long is the ADA2 protein?
The Homo sapiens ADA2 protein (UniProt Q9NZK5) is 511 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZK5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZK5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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