Group IIE secretory phospholipase A2 (PLA2G2E)
Homo sapiens — UniProt Q9NZK7
Data last refreshed: (UniProt release unknown)
Key facts
Group IIE secretory phospholipase A2 (PLA2G2E) is a protein from Homo sapiens identified by UniProt accession Q9NZK7, 142 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q9NZK7; gene symbol PLA2G2E.
- Organism: Homo sapiens.
- Length: 142 amino acids.
- Top disease associations (Open Targets): ulcerative colitis, breast adenocarcinoma and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Group IIE secretory phospholipase A2 |
|---|---|
| UniProt accession | Q9NZK7 |
| Gene | PLA2G2E |
| Organism | Homo sapiens |
| Length | 142 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- ulcerative colitis · score 0.31
- breast adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.10
- dilated cardiomyopathy 1L · score 0.05
- Crohn's disease · score 0.03
- rheumatoid arthritis · score 0.03
- inflammatory bowel disease · score 0.02
- psoriasis · score 0.02
- influenza · score 0.02
- ankylosing spondylitis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZK7-F1 | alphafold | PREDICTED | 90.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZK7.
Amino-acid sequence (142 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLA2G2E?
The strongest Open Targets associations for PLA2G2E are ulcerative colitis, breast adenocarcinoma, cutaneous melanoma, dilated cardiomyopathy 1L and Crohn's disease.
How long is the PLA2G2E protein?
The Homo sapiens PLA2G2E protein (UniProt Q9NZK7) is 142 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZK7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZK7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.