Hsp70-binding protein 1 (HSPBP1)
Homo sapiens — UniProt Q9NZL4
Data last refreshed: (UniProt release unknown)
Key facts
Hsp70-binding protein 1 (HSPBP1) is a protein from Homo sapiens identified by UniProt accession Q9NZL4, 359 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.
- UniProt accession: Q9NZL4; gene symbol HSPBP1.
- Organism: Homo sapiens.
- Length: 359 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean platelet volume and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hsp70-binding protein 1 |
|---|---|
| UniProt accession | Q9NZL4 |
| Gene | HSPBP1 |
| Organism | Homo sapiens |
| Length | 359 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (135)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- mean platelet volume · score 0.33
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failures 50 · score 0.06
- spinocerebellar ataxia type 32 · score 0.06
- spermatogenic failure 25 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- isochromosomy Yp · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZL4-F1 | alphafold | PREDICTED | 83.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZL4.
Amino-acid sequence (359 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HSPBP1?
The strongest Open Targets associations for HSPBP1 are neurodegenerative disease, mean platelet volume, azoospermia, partial chromosome Y deletion and male infertility with teratozoospermia due to single gene mutation.
How long is the HSPBP1 protein?
The Homo sapiens HSPBP1 protein (UniProt Q9NZL4) is 359 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZL4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZL4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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