Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)
Homo sapiens — UniProt Q9NZL6
Data last refreshed: (UniProt release unknown)
Key facts
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1) is a protein from Homo sapiens identified by UniProt accession Q9NZL6, 768 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.
- UniProt accession: Q9NZL6; gene symbol RGL1.
- Organism: Homo sapiens.
- Length: 768 amino acids.
- Top disease associations (Open Targets): aspartate aminotransferase measurement, reticulocyte count and aspartate aminotransferase to alanine aminotransferase ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ral guanine nucleotide dissociation stimulator-like 1 |
|---|---|
| UniProt accession | Q9NZL6 |
| Gene | RGL1 |
| Organism | Homo sapiens |
| Length | 768 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (121)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.41
- reticulocyte count · score 0.31
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.27
- reticulocyte measurement · score 0.26
- type 1 diabetes mellitus · score 0.20
- osteoarthritis, hip · score 0.19
- chronotype measurement · score 0.19
- Immature Reticulocyte Fraction Measurement · score 0.18
- total joint arthroplasty · score 0.16
- osteoarthritis, knee · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZL6-F1 | alphafold | PREDICTED | 70.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZL6.
Amino-acid sequence (768 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RGL1?
The strongest Open Targets associations for RGL1 are aspartate aminotransferase measurement, reticulocyte count, aspartate aminotransferase to alanine aminotransferase ratio, reticulocyte measurement and type 1 diabetes mellitus.
How long is the RGL1 protein?
The Homo sapiens RGL1 protein (UniProt Q9NZL6) is 768 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZL6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZL6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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