Methionine adenosyltransferase 2 subunit beta (MAT2B)
Homo sapiens — UniProt Q9NZL9
Data last refreshed: (UniProt release unknown)
Key facts
Methionine adenosyltransferase 2 subunit beta (MAT2B) is a protein from Homo sapiens identified by UniProt accession Q9NZL9, 334 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q9NZL9; gene symbol MAT2B.
- Organism: Homo sapiens.
- Length: 334 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, attention deficit hyperactivity disorder and antisocial behaviour measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Methionine adenosyltransferase 2 subunit beta |
|---|---|
| UniProt accession | Q9NZL9 |
| Gene | MAT2B |
| Organism | Homo sapiens |
| Length | 334 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.23
- attention deficit hyperactivity disorder · score 0.19
- antisocial behaviour measurement · score 0.19
- substance abuse · score 0.19
- amyloid-beta measurement · score 0.19
- age at first sexual intercourse measurement · score 0.18
- smoking status measurement · score 0.16
- chronotype measurement · score 0.12
- diffuse plaque measurement · score 0.11
- age-related hearing impairment · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZL9-F1 | alphafold | PREDICTED | 93.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZL9.
Amino-acid sequence (334 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAT2B?
The strongest Open Targets associations for MAT2B are breast adenocarcinoma, attention deficit hyperactivity disorder, antisocial behaviour measurement, substance abuse and amyloid-beta measurement.
How long is the MAT2B protein?
The Homo sapiens MAT2B protein (UniProt Q9NZL9) is 334 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZL9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZL9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.