BRD4-interacting chromatin-remodeling complex-associated protein (BICRA)

Homo sapiens — UniProt Q9NZM4

Gene: BICRAHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

BRD4-interacting chromatin-remodeling complex-associated protein (BICRA) is a protein from Homo sapiens identified by UniProt accession Q9NZM4, 1560 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

UniProt accession: Q9NZM4; gene symbol BICRA.
Organism: Homo sapiens.
Length: 1560 amino acids.
Top disease associations (Open Targets): Coffin-Siris syndrome 12, Intellectual disability and serum gamma-glutamyl transferase measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	BRD4-interacting chromatin-remodeling complex-associated protein
UniProt accession	Q9NZM4
Gene	BICRA
Organism	Homo sapiens
Length	1560 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

Coffin-Siris syndrome 12 · score 0.63
Intellectual disability · score 0.33
serum gamma-glutamyl transferase measurement · score 0.31
hair shape measurement · score 0.25
sex hormone-binding globulin measurement · score 0.23
secondary malignant neoplasm · score 0.22
balding measurement · score 0.22
smoking status measurement · score 0.17
high density lipoprotein cholesterol measurement · score 0.15
Neurodevelopmental disorder · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NZM4-F1	alphafold	PREDICTED	41.87	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZM4.

Amino-acid sequence (1560 residues)

MDDEDGRCLL DVICDPQALN DFLHGSEKLD SDDLLDNPGE AQSAFYEGPG LHVQEASGNH LNPEPNQPAP SVDLDFLEDD ILGSPATGGG GGGSGGADQP CDILQQSLQE ANITEQTLEA EAELDLGPFQ LPTLQPADGG AGPTGAGGAA AVAAGPQALF PGSTDLLGLQ GPPTVLTHQA LVPPQDVVNK ALSVQPFLQP VGLGNVTLQP IPGLQGLPNG SPGGATAATL GLAPIQVVGQ PVMALNTPTS QLLAKQVPVS GYLASAAGPS EPVTLASAGV SPQGAGLVIQ KNLSAAVATT LNGNSVFGGA GAASAPTGTP SGQPLAVAPG LGSSPLVPAP NVILHRTPTP IQPKPAGVLP PKLYQLTPKP FAPAGATLTI QGEPGALPQQ PKAPQNLTFM AAGKAGQNVV LSGFPAPALQ ANVFKQPPAT TTGAAPPQPP GALSKPMSVH LLNQGSSIVI PAQHMLPGQN QFLLPGAPAV QLPQQLSALP ANVGGQILAA AAPHTGGQLI ANPILTNQNL AGPLSLGPVL APHSGAHSAH ILSAAPIQVG QPALFQMPVS LAAGSLPTQS QPAPAGPAAT TVLQGVTLPP SAVAMLNTPD GLVQPATPAA ATGEAAPVLT VQPAPQAPPA VSTPLPLGLQ QPQAQQPPQA PTPQAAAPPQ ATTPQPSPGL ASSPEKIVLG QPPSATPTAI LTQDSLQMFL PQERSQQPLS AEGPHLSVPA SVIVSAPPPA QDPAPATPVA KGAGLGPQAP DSQASPAPAP QIPAAAPLKG PGPSSSPSLP HQAPLGDSPH LPSPHPTRPP SRPPSRPQSV SRPPSEPPLH PCPPPQAPPT LPGIFVIQNQ LGVPPPASNP APTAPGPPQP PLRPQSQPPE GPLPPAPHLP PSSTSSAVAS SSETSSRLPA PTPSDFQLQF PPSQGPHKSP TPPPTLHLVP EPAAPPPPPP RTFQMVTTPF PALPQPKALL ERFHQVPSGI ILQNKAGGAP AAPQTSTSLG PLTSPAASVL VSGQAPSGTP TAPSHAPAPA PMAATGLPPL LPAENKAFAS NLPTLNVAKA ASSGPGKPSG LQYESKLSGL KKPPTLQPSK EACFLEHLHK HQGSVLHPDY KTAFPSFEDA LHRLLPYHVY QGALPSPSDY HKVDEEFETV STQLLKRTQA MLNKYRLLLL EESRRVSPSA EMVMIDRMFI QEEKTTLALD KQLAKEKPDE YVSSSRSLGL PIAASSEGHR LPGHGPLSSS APGASTQPPP HLPTKLVIRH GGAGGSPSVT WARASSSLSS SSSSSSAASS LDADEDGPMP SRNRPPIKTY EARSRIGLKL KIKQEAGLSK VVHNTALDPV HQPPPPPATL KVAEPPPRPP PPPPPTGQMN GTVDHPPPAA PERKPLGTAP HCPRLPLRKT YRENVGGPGA PEGTPAGRAR GGSPAPLPAK VDEATSGLIR ELAAVEDELY QRMLKGPPPE PAASAAQGTG DPDWEAPGLP PAKRRKSESP DVDQASFSSD SPQDDTLTEH LQSAIDSILN LQQAPGRTPA PSYPHAASAG TPASPPPLHR PEAYPPSSHN GGLGARTLTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with BICRA?

The strongest Open Targets associations for BICRA are Coffin-Siris syndrome 12, Intellectual disability, serum gamma-glutamyl transferase measurement, hair shape measurement and sex hormone-binding globulin measurement.

How long is the BICRA protein?

The Homo sapiens BICRA protein (UniProt Q9NZM4) is 1560 amino acids long.

Browse: Targets: B · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9NZM4 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9NZM4 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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