Ribosome biogenesis protein NOP53 (NOP53)
Homo sapiens — UniProt Q9NZM5
Data last refreshed: (UniProt release unknown)
Key facts
Ribosome biogenesis protein NOP53 (NOP53) is a protein from Homo sapiens identified by UniProt accession Q9NZM5, 478 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q9NZM5; gene symbol NOP53.
- Organism: Homo sapiens.
- Length: 478 amino acids.
- Top disease associations (Open Targets): drug use measurement, non-small cell lung carcinoma and viral disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribosome biogenesis protein NOP53 |
|---|---|
| UniProt accession | Q9NZM5 |
| Gene | NOP53 |
| Organism | Homo sapiens |
| Length | 478 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- drug use measurement · score 0.09
- non-small cell lung carcinoma · score 0.06
- viral disease · score 0.05
- neoplasm · score 0.03
- hepatocellular carcinoma · score 0.03
- infection · score 0.03
- infect · score 0.03
- cancer · score 0.02
- glioblastoma · score 0.02
- renal cell carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZM5-F1 | alphafold | PREDICTED | 78.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZM5.
Amino-acid sequence (478 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NOP53?
The strongest Open Targets associations for NOP53 are drug use measurement, non-small cell lung carcinoma, viral disease, neoplasm and hepatocellular carcinoma.
How long is the NOP53 protein?
The Homo sapiens NOP53 protein (UniProt Q9NZM5) is 478 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZM5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZM5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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