Polycystin-2-like protein 2 (PKD2L2)
Homo sapiens — UniProt Q9NZM6
Data last refreshed: (UniProt release unknown)
Key facts
Polycystin-2-like protein 2 (PKD2L2) is a protein from Homo sapiens identified by UniProt accession Q9NZM6, 624 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q9NZM6; gene symbol PKD2L2.
- Organism: Homo sapiens.
- Length: 624 amino acids.
- Top disease associations (Open Targets): hematocrit, hemoglobin measurement and atrial fibrillation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polycystin-2-like protein 2 |
|---|---|
| UniProt accession | Q9NZM6 |
| Gene | PKD2L2 |
| Organism | Homo sapiens |
| Length | 624 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- hematocrit · score 0.19
- hemoglobin measurement · score 0.17
- atrial fibrillation · score 0.15
- atrial flutter · score 0.14
- erythrocyte count · score 0.12
- red blood cell density measurement · score 0.11
- blood pressure · score 0.10
- balding measurement · score 0.09
- attention deficit hyperactivity disorder · score 0.08
- attention deficit-hyperactivity disorder 8 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZM6-F1 | alphafold | PREDICTED | 81.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZM6.
Amino-acid sequence (624 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PKD2L2?
The strongest Open Targets associations for PKD2L2 are hematocrit, hemoglobin measurement, atrial fibrillation, atrial flutter and erythrocyte count.
How long is the PKD2L2 protein?
The Homo sapiens PKD2L2 protein (UniProt Q9NZM6) is 624 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZM6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZM6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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