Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)
Homo sapiens — UniProt Q9NZN1
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a protein from Homo sapiens identified by UniProt accession Q9NZN1, 696 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: Q9NZN1; gene symbol IL1RAPL1.
- Organism: Homo sapiens.
- Length: 696 amino acids.
- Top disease associations (Open Targets): intellectual disability, X-linked 21, X-linked non-syndromic intellectual disability and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-1 receptor accessory protein-like 1 |
|---|---|
| UniProt accession | Q9NZN1 |
| Gene | IL1RAPL1 |
| Organism | Homo sapiens |
| Length | 696 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- intellectual disability, X-linked 21 · score 0.67
- X-linked non-syndromic intellectual disability · score 0.66
- Intellectual disability · score 0.53
- non-syndromic X-linked intellectual disability · score 0.41
- genetic disorder · score 0.34
- Vitiligo · score 0.18
- schizophrenia · score 0.11
- neoplasm · score 0.08
- neuroticism measurement · score 0.03
- chronotype measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZN1-F1 | alphafold | PREDICTED | 76.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZN1.
Amino-acid sequence (696 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IL1RAPL1?
The strongest Open Targets associations for IL1RAPL1 are intellectual disability, X-linked 21, X-linked non-syndromic intellectual disability, Intellectual disability, non-syndromic X-linked intellectual disability and genetic disorder.
How long is the IL1RAPL1 protein?
The Homo sapiens IL1RAPL1 protein (UniProt Q9NZN1) is 696 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZN1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZN1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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