EH domain-containing protein 2 (EHD2)
Homo sapiens — UniProt Q9NZN4
Data last refreshed: (UniProt release unknown)
Key facts
EH domain-containing protein 2 (EHD2) is a protein from Homo sapiens identified by UniProt accession Q9NZN4, 543 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9NZN4; gene symbol EHD2.
- Organism: Homo sapiens.
- Length: 543 amino acids.
- Top disease associations (Open Targets): ovarian cancer, breast adenocarcinoma and esophageal cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | EH domain-containing protein 2 |
|---|---|
| UniProt accession | Q9NZN4 |
| Gene | EHD2 |
| Organism | Homo sapiens |
| Length | 543 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.15
- drug use measurement · score 0.12
- lean body mass · score 0.12
- hepatocellular carcinoma · score 0.07
- Age-related nuclear cataract · score 0.06
- hair shape measurement · score 0.03
- neoplasm · score 0.03
- nonpapillary renal cell carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZN4-F1 | alphafold | PREDICTED | 86.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZN4.
Amino-acid sequence (543 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EHD2?
The strongest Open Targets associations for EHD2 are ovarian cancer, breast adenocarcinoma, esophageal cancer, drug use measurement and lean body mass.
How long is the EHD2 protein?
The Homo sapiens EHD2 protein (UniProt Q9NZN4) is 543 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZN4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZN4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.