CCR4-NOT transcription complex subunit 2 (CNOT2)
Homo sapiens — UniProt Q9NZN8
Data last refreshed: (UniProt release unknown)
Key facts
CCR4-NOT transcription complex subunit 2 (CNOT2) is a protein from Homo sapiens identified by UniProt accession Q9NZN8, 540 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q9NZN8; gene symbol CNOT2.
- Organism: Homo sapiens.
- Length: 540 amino acids.
- Top disease associations (Open Targets): intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies, genetic disorder and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CCR4-NOT transcription complex subunit 2 |
|---|---|
| UniProt accession | Q9NZN8 |
| Gene | CNOT2 |
| Organism | Homo sapiens |
| Length | 540 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies · score 0.51
- genetic disorder · score 0.41
- neurodegenerative disease · score 0.40
- Neurodevelopmental disorder · score 0.27
- glioblastoma multiforme · score 0.25
- breast adenocarcinoma · score 0.25
- gastric adenocarcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- squamous cell lung carcinoma · score 0.23
- urinary bladder cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZN8-F1 | alphafold | PREDICTED | 59.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZN8.
Amino-acid sequence (540 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CNOT2?
The strongest Open Targets associations for CNOT2 are intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies, genetic disorder, neurodegenerative disease, Neurodevelopmental disorder and glioblastoma multiforme.
How long is the CNOT2 protein?
The Homo sapiens CNOT2 protein (UniProt Q9NZN8) is 540 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZN8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZN8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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