Complement C1r subcomponent-like protein (C1RL)
Homo sapiens — UniProt Q9NZP8
Data last refreshed: (UniProt release unknown)
Key facts
Complement C1r subcomponent-like protein (C1RL) is a protein from Homo sapiens identified by UniProt accession Q9NZP8, 487 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q9NZP8; gene symbol C1RL.
- Organism: Homo sapiens.
- Length: 487 amino acids.
- Top disease associations (Open Targets): blood protein measurement, complement C1r subcomponent measurement and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Complement C1r subcomponent-like protein |
|---|---|
| UniProt accession | Q9NZP8 |
| Gene | C1RL |
| Organism | Homo sapiens |
| Length | 487 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.30
- complement C1r subcomponent measurement · score 0.10
- eosinophil count · score 0.09
- glioblastoma multiforme · score 0.09
- eosinophil percentage of leukocytes · score 0.07
- platelet crit · score 0.06
- gonorrhea · score 0.06
- hip dysplasia, Beukes type · score 0.06
- Blount disease · score 0.05
- coxopodopatellar syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZP8-F1 | alphafold | PREDICTED | 77.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZP8.
Amino-acid sequence (487 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with C1RL?
The strongest Open Targets associations for C1RL are blood protein measurement, complement C1r subcomponent measurement, eosinophil count, glioblastoma multiforme and eosinophil percentage of leukocytes.
How long is the C1RL protein?
The Homo sapiens C1RL protein (UniProt Q9NZP8) is 487 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZP8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZP8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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