Programmed cell death 1 ligand 1 (CD274)
Homo sapiens — UniProt Q9NZQ7
Data last refreshed: (UniProt release unknown)
Key facts
Programmed cell death 1 ligand 1 (CD274) is a protein from Homo sapiens identified by UniProt accession Q9NZQ7, 290 residues long. MolForge cross-references it against 6 known binders and 1,721 disease associations.
- UniProt accession: Q9NZQ7; gene symbol CD274.
- Organism: Homo sapiens.
- Length: 290 amino acids.
- Approved drugs acting on it (DrugCentral): Atezolizumab, Cosibelimab-Ipdl, Sugemalimab, Avelumab and Durvalumab.
- Top disease associations (Open Targets): non-small cell lung carcinoma, hepatocellular carcinoma and small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Programmed cell death 1 ligand 1 |
|---|---|
| UniProt accession | Q9NZQ7 |
| Gene | CD274 |
| Organism | Homo sapiens |
| Length | 290 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (5)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (1721)
Diseases linked to this target (Open Targets).
- non-small cell lung carcinoma · score 0.67
- hepatocellular carcinoma · score 0.64
- small cell lung carcinoma · score 0.61
- neoplasm · score 0.58
- Merkel cell skin cancer · score 0.58
- gastric adenocarcinoma · score 0.56
- breast cancer · score 0.55
- lung cancer · score 0.54
- urothelial carcinoma · score 0.52
- urinary bladder carcinoma · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZQ7-F1 | alphafold | PREDICTED | 88.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZQ7.
Amino-acid sequence (290 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target CD274?
DrugCentral lists 5 approved drugs whose mechanism of action is CD274: Atezolizumab, Cosibelimab-Ipdl, Sugemalimab, Avelumab and Durvalumab.
Which diseases are associated with CD274?
The strongest Open Targets associations for CD274 are non-small cell lung carcinoma, hepatocellular carcinoma, small cell lung carcinoma, neoplasm and Merkel cell skin cancer.
How long is the CD274 protein?
The Homo sapiens CD274 protein (UniProt Q9NZQ7) is 290 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZQ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZQ7 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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