Transient receptor potential cation channel subfamily M member 5 (TRPM5)
Homo sapiens — UniProt Q9NZQ8
Data last refreshed: (UniProt release unknown)
Key facts
Transient receptor potential cation channel subfamily M member 5 (TRPM5) is a protein from Homo sapiens identified by UniProt accession Q9NZQ8, 1165 residues long. MolForge cross-references it against 1 known binders and 94 disease associations.
- UniProt accession: Q9NZQ8; gene symbol TRPM5.
- Organism: Homo sapiens.
- Length: 1165 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): neurodegenerative disease, glioblastoma multiforme and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transient receptor potential cation channel subfamily M member 5 |
|---|---|
| UniProt accession | Q9NZQ8 |
| Gene | TRPM5 |
| Organism | Homo sapiens |
| Length | 1165 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (94)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- type 2 diabetes mellitus · score 0.13
- protein measurement · score 0.13
- lung adenocarcinoma · score 0.12
- head and neck squamous cell carcinoma · score 0.12
- QT interval · score 0.10
- electrocardiography · score 0.10
- T wave morphology measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZQ8-F1 | alphafold | PREDICTED | 77.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZQ8.
Amino-acid sequence (1165 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRPM5?
The strongest Open Targets associations for TRPM5 are neurodegenerative disease, glioblastoma multiforme, breast adenocarcinoma, type 2 diabetes mellitus and protein measurement.
How long is the TRPM5 protein?
The Homo sapiens TRPM5 protein (UniProt Q9NZQ8) is 1165 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZQ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZQ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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