Tropomodulin-2 (TMOD2)
Homo sapiens — UniProt Q9NZR1
Data last refreshed: (UniProt release unknown)
Key facts
Tropomodulin-2 (TMOD2) is a protein from Homo sapiens identified by UniProt accession Q9NZR1, 351 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9NZR1; gene symbol TMOD2.
- Organism: Homo sapiens.
- Length: 351 amino acids.
- Top disease associations (Open Targets): mean reticulocyte volume, ovarian cancer and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tropomodulin-2 |
|---|---|
| UniProt accession | Q9NZR1 |
| Gene | TMOD2 |
| Organism | Homo sapiens |
| Length | 351 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- mean reticulocyte volume · score 0.24
- ovarian cancer · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- body height · score 0.18
- glioblastoma multiforme · score 0.17
- endometrial cancer · score 0.13
- developmental and epileptic encephalopathy, 13 · score 0.12
- developmental and epileptic encephalopathy · score 0.12
- intelligence · score 0.12
- urinary bladder cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZR1-F1 | alphafold | PREDICTED | 83.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZR1.
Amino-acid sequence (351 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMOD2?
The strongest Open Targets associations for TMOD2 are mean reticulocyte volume, ovarian cancer, head and neck squamous cell carcinoma, body height and glioblastoma multiforme.
How long is the TMOD2 protein?
The Homo sapiens TMOD2 protein (UniProt Q9NZR1) is 351 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZR1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZR1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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