Visual system homeobox 1 (VSX1)
Homo sapiens — UniProt Q9NZR4
Data last refreshed: (UniProt release unknown)
Key facts
Visual system homeobox 1 (VSX1) is a protein from Homo sapiens identified by UniProt accession Q9NZR4, 365 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q9NZR4; gene symbol VSX1.
- Organism: Homo sapiens.
- Length: 365 amino acids.
- Top disease associations (Open Targets): keratoconus 1, craniofacial anomalies and anterior segment dysgenesis syndrome and posterior polymorphous corneal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Visual system homeobox 1 |
|---|---|
| UniProt accession | Q9NZR4 |
| Gene | VSX1 |
| Organism | Homo sapiens |
| Length | 365 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- keratoconus 1 · score 0.76
- craniofacial anomalies and anterior segment dysgenesis syndrome · score 0.47
- posterior polymorphous corneal dystrophy · score 0.42
- mean corpuscular hemoglobin · score 0.27
- neurodegenerative disease · score 0.25
- alcohol consumption measurement · score 0.19
- genetic disorder · score 0.19
- body mass index · score 0.18
- gut microbiome measurement · score 0.17
- keratoconus · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZR4-F1 | alphafold | PREDICTED | 60.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZR4.
Amino-acid sequence (365 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VSX1?
The strongest Open Targets associations for VSX1 are keratoconus 1, craniofacial anomalies and anterior segment dysgenesis syndrome, posterior polymorphous corneal dystrophy, mean corpuscular hemoglobin and neurodegenerative disease.
How long is the VSX1 protein?
The Homo sapiens VSX1 protein (UniProt Q9NZR4) is 365 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZR4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZR4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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