Bifunctional apoptosis regulator (BFAR)
Homo sapiens — UniProt Q9NZS9
Data last refreshed: (UniProt release unknown)
Key facts
Bifunctional apoptosis regulator (BFAR) is a protein from Homo sapiens identified by UniProt accession Q9NZS9, 450 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q9NZS9; gene symbol BFAR.
- Organism: Homo sapiens.
- Length: 450 amino acids.
- Top disease associations (Open Targets): body mass index, forced expiratory volume and vital capacity.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bifunctional apoptosis regulator |
|---|---|
| UniProt accession | Q9NZS9 |
| Gene | BFAR |
| Organism | Homo sapiens |
| Length | 450 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- body mass index · score 0.28
- forced expiratory volume · score 0.17
- vital capacity · score 0.12
- cancer · score 0.05
- body height · score 0.05
- diastolic blood pressure · score 0.04
- neoplasm · score 0.04
- mathematical ability · score 0.04
- self reported educational attainment · score 0.04
- brain aneurysm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZS9-F1 | alphafold | PREDICTED | 81.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZS9.
Amino-acid sequence (450 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BFAR?
The strongest Open Targets associations for BFAR are body mass index, forced expiratory volume, vital capacity, cancer and body height.
How long is the BFAR protein?
The Homo sapiens BFAR protein (UniProt Q9NZS9) is 450 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZS9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZS9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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