Leucine-rich repeat transmembrane protein FLRT3 (FLRT3)
Homo sapiens — UniProt Q9NZU0
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat transmembrane protein FLRT3 (FLRT3) is a protein from Homo sapiens identified by UniProt accession Q9NZU0, 649 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.
- UniProt accession: Q9NZU0; gene symbol FLRT3.
- Organism: Homo sapiens.
- Length: 649 amino acids.
- Top disease associations (Open Targets): Kallmann syndrome, serum gamma-glutamyl transferase measurement and serum alanine aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat transmembrane protein FLRT3 |
|---|---|
| UniProt accession | Q9NZU0 |
| Gene | FLRT3 |
| Organism | Homo sapiens |
| Length | 649 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (94)
Diseases linked to this target (Open Targets).
- Kallmann syndrome · score 0.48
- serum gamma-glutamyl transferase measurement · score 0.32
- serum alanine aminotransferase measurement · score 0.27
- lung adenocarcinoma · score 0.26
- breast adenocarcinoma · score 0.25
- alkaline phosphatase measurement · score 0.23
- femoral neck bone mineral density · score 0.22
- cutaneous melanoma · score 0.21
- glomerular filtration rate · score 0.21
- receptor-type tyrosine-protein kinase flt3 measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZU0-F1 | alphafold | PREDICTED | 74.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZU0.
Amino-acid sequence (649 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FLRT3?
The strongest Open Targets associations for FLRT3 are Kallmann syndrome, serum gamma-glutamyl transferase measurement, serum alanine aminotransferase measurement, lung adenocarcinoma and breast adenocarcinoma.
How long is the FLRT3 protein?
The Homo sapiens FLRT3 protein (UniProt Q9NZU0) is 649 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZU0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZU0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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