A-type voltage-gated potassium channel KCND2 (KCND2)
Homo sapiens — UniProt Q9NZV8
Data last refreshed: (UniProt release unknown)
Key facts
A-type voltage-gated potassium channel KCND2 (KCND2) is a protein from Homo sapiens identified by UniProt accession Q9NZV8, 630 residues long. MolForge cross-references it against 1 known binders and 163 disease associations.
- UniProt accession: Q9NZV8; gene symbol KCND2.
- Organism: Homo sapiens.
- Length: 630 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, Myasthenia gravis and early myoclonic encephalopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A-type voltage-gated potassium channel KCND2 |
|---|---|
| UniProt accession | Q9NZV8 |
| Gene | KCND2 |
| Organism | Homo sapiens |
| Length | 630 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (163)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- early myoclonic encephalopathy · score 0.52
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- genetic disorder · score 0.45
- secondary progressive multiple sclerosis · score 0.43
- Global developmental delay · score 0.37
- Seizure · score 0.37
- anterior ischemic optic neuropathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZV8-F1 | alphafold | PREDICTED | 71.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZV8.
Amino-acid sequence (630 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCND2?
The strongest Open Targets associations for KCND2 are multiple sclerosis, Myasthenia gravis, early myoclonic encephalopathy, small cell carcinoma and Muscle weakness.
How long is the KCND2 protein?
The Homo sapiens KCND2 protein (UniProt Q9NZV8) is 630 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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