Dentin sialophosphoprotein (DSPP)
Homo sapiens — UniProt Q9NZW4
Data last refreshed: (UniProt release unknown)
Key facts
Dentin sialophosphoprotein (DSPP) is a protein from Homo sapiens identified by UniProt accession Q9NZW4, 1301 residues long. MolForge cross-references it against 0 known binders and 242 disease associations.
- UniProt accession: Q9NZW4; gene symbol DSPP.
- Organism: Homo sapiens.
- Length: 1301 amino acids.
- Top disease associations (Open Targets): dentinogenesis imperfecta type 2, deafness, autosomal dominant 39, with dentinogenesis imperfecta 1 and dentinogenesis imperfecta type 3.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dentin sialophosphoprotein |
|---|---|
| UniProt accession | Q9NZW4 |
| Gene | DSPP |
| Organism | Homo sapiens |
| Length | 1301 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (242)
Diseases linked to this target (Open Targets).
- dentinogenesis imperfecta type 2 · score 0.78
- deafness, autosomal dominant 39, with dentinogenesis imperfecta 1 · score 0.69
- dentinogenesis imperfecta type 3 · score 0.68
- dentin dysplasia type II · score 0.66
- dentinogenesis imperfecta · score 0.55
- dentin dysplasia · score 0.51
- dentin dysplasia type I · score 0.38
- hearing loss · score 0.37
- neurodegenerative disease · score 0.28
- breast adenocarcinoma · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NZW4-F1 | alphafold | PREDICTED | 39.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NZW4.
Amino-acid sequence (1301 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DSPP?
The strongest Open Targets associations for DSPP are dentinogenesis imperfecta type 2, deafness, autosomal dominant 39, with dentinogenesis imperfecta 1, dentinogenesis imperfecta type 3, dentin dysplasia type II and dentinogenesis imperfecta.
How long is the DSPP protein?
The Homo sapiens DSPP protein (UniProt Q9NZW4) is 1301 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NZW4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NZW4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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