Mediator of RNA polymerase II transcription subunit 11 (MED11)
Homo sapiens — UniProt Q9P086
Data last refreshed: (UniProt release unknown)
Key facts
Mediator of RNA polymerase II transcription subunit 11 (MED11) is a protein from Homo sapiens identified by UniProt accession Q9P086, 117 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9P086; gene symbol MED11.
- Organism: Homo sapiens.
- Length: 117 amino acids.
- Top disease associations (Open Targets): neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities, neurodegenerative disease and Neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 11 |
|---|---|
| UniProt accession | Q9P086 |
| Gene | MED11 |
| Organism | Homo sapiens |
| Length | 117 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities · score 0.61
- neurodegenerative disease · score 0.19
- Neurodevelopmental disorder · score 0.18
- C-X-C motif chemokine 16 measurement · score 0.13
- MODY · score 0.07
- lymphocyte count · score 0.06
- mean arterial pressure · score 0.05
- diastolic blood pressure · score 0.05
- diabetes mellitus, permanent neonatal 4 · score 0.04
- diabetes mellitus, transient neonatal, 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P086-F1 | alphafold | PREDICTED | 87.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P086.
Amino-acid sequence (117 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MED11?
The strongest Open Targets associations for MED11 are neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities, neurodegenerative disease, Neurodevelopmental disorder, C-X-C motif chemokine 16 measurement and MODY.
How long is the MED11 protein?
The Homo sapiens MED11 protein (UniProt Q9P086) is 117 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P086 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P086 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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