[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1)
Homo sapiens — UniProt Q9P0J1
Data last refreshed: (UniProt release unknown)
Key facts
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) is a protein from Homo sapiens identified by UniProt accession Q9P0J1, 537 residues long. MolForge cross-references it against 0 known binders and 288 disease associations.
- UniProt accession: Q9P0J1; gene symbol PDP1.
- Organism: Homo sapiens.
- Length: 537 amino acids.
- Top disease associations (Open Targets): pyruvate dehydrogenase phosphatase deficiency, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial |
|---|---|
| UniProt accession | Q9P0J1 |
| Gene | PDP1 |
| Organism | Homo sapiens |
| Length | 537 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (288)
Diseases linked to this target (Open Targets).
- pyruvate dehydrogenase phosphatase deficiency · score 0.75
- neurodegenerative disease · score 0.27
- genetic disorder · score 0.19
- neoplasm · score 0.11
- acute myeloid leukemia · score 0.08
- hepatocellular carcinoma · score 0.07
- cancer · score 0.06
- breast cancer · score 0.06
- insulin resistance · score 0.05
- oral squamous cell carcinoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0J1-F1 | alphafold | PREDICTED | 83.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0J1.
Amino-acid sequence (537 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PDP1?
The strongest Open Targets associations for PDP1 are pyruvate dehydrogenase phosphatase deficiency, neurodegenerative disease, genetic disorder, neoplasm and acute myeloid leukemia.
How long is the PDP1 protein?
The Homo sapiens PDP1 protein (UniProt Q9P0J1) is 537 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0J1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0J1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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