E3 ubiquitin-protein ligase KCMF1 (KCMF1)
Homo sapiens — UniProt Q9P0J7
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase KCMF1 (KCMF1) is a protein from Homo sapiens identified by UniProt accession Q9P0J7, 381 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9P0J7; gene symbol KCMF1.
- Organism: Homo sapiens.
- Length: 381 amino acids.
- Top disease associations (Open Targets): pyknoachondrogenesis, oral squamous cell carcinoma and preeclampsia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase KCMF1 |
|---|---|
| UniProt accession | Q9P0J7 |
| Gene | KCMF1 |
| Organism | Homo sapiens |
| Length | 381 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- pyknoachondrogenesis · score 0.03
- oral squamous cell carcinoma · score 0.02
- preeclampsia · score 0.01
- renal cell carcinoma · score 0.01
- cancer · score 0.01
- Ewing sarcoma · score 0.01
- mesenchymal chondrosarcoma · score 0.01
- rhabdomyosarcoma · score 0.01
- mansonelliasis · score 0.01
- lymphoblastic lymphoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0J7-F1 | alphafold | PREDICTED | 70.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0J7.
Amino-acid sequence (381 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCMF1?
The strongest Open Targets associations for KCMF1 are pyknoachondrogenesis, oral squamous cell carcinoma, preeclampsia, renal cell carcinoma and cancer.
How long is the KCMF1 protein?
The Homo sapiens KCMF1 protein (UniProt Q9P0J7) is 381 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0J7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0J7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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