Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)
Homo sapiens — UniProt Q9P0K1
Data last refreshed: (UniProt release unknown)
Key facts
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) is a protein from Homo sapiens identified by UniProt accession Q9P0K1, 906 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q9P0K1; gene symbol ADAM22.
- Organism: Homo sapiens.
- Length: 906 amino acids.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, 61, developmental and epileptic encephalopathy and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Disintegrin and metalloproteinase domain-containing protein 22 |
|---|---|
| UniProt accession | Q9P0K1 |
| Gene | ADAM22 |
| Organism | Homo sapiens |
| Length | 906 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 61 · score 0.66
- developmental and epileptic encephalopathy · score 0.59
- blood protein measurement · score 0.32
- Intellectual disability · score 0.27
- Seizure · score 0.27
- genetic disorder · score 0.19
- appendicular lean mass · score 0.16
- schizophrenia · score 0.09
- cardiac hypertrophy · score 0.07
- metabolite measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0K1-F1 | alphafold | PREDICTED | 73.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0K1.
Amino-acid sequence (906 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAM22?
The strongest Open Targets associations for ADAM22 are developmental and epileptic encephalopathy, 61, developmental and epileptic encephalopathy, blood protein measurement, Intellectual disability and Seizure.
How long is the ADAM22 protein?
The Homo sapiens ADAM22 protein (UniProt Q9P0K1) is 906 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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