Core histone macro-H2A.2 (MACROH2A2)
Homo sapiens — UniProt Q9P0M6
Data last refreshed: (UniProt release unknown)
Key facts
Core histone macro-H2A.2 (MACROH2A2) is a protein from Homo sapiens identified by UniProt accession Q9P0M6, 372 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9P0M6; gene symbol MACROH2A2.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): eyelid sagging measurement, glioblastoma multiforme and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Core histone macro-H2A.2 |
|---|---|
| UniProt accession | Q9P0M6 |
| Gene | MACROH2A2 |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- eyelid sagging measurement · score 0.31
- glioblastoma multiforme · score 0.07
- PHF-tau measurement · score 0.06
- Senior-Boichis syndrome · score 0.04
- Hepatic veno-occlusive disease - immunodeficiency · score 0.03
- hemoglobin H disease · score 0.03
- dominant beta-thalassemia · score 0.03
- Tyrosinemia type 1 · score 0.03
- sclerosing cholangitis · score 0.03
- neoplasm · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0M6-F1 | alphafold | PREDICTED | 82.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0M6.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MACROH2A2?
The strongest Open Targets associations for MACROH2A2 are eyelid sagging measurement, glioblastoma multiforme, PHF-tau measurement, Senior-Boichis syndrome and Hepatic veno-occlusive disease - immunodeficiency.
How long is the MACROH2A2 protein?
The Homo sapiens MACROH2A2 protein (UniProt Q9P0M6) is 372 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0M6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0M6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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