Large ribosomal subunit protein bL27m (MRPL27)
Homo sapiens — UniProt Q9P0M9
Data last refreshed: (UniProt release unknown)
Key facts
Large ribosomal subunit protein bL27m (MRPL27) is a protein from Homo sapiens identified by UniProt accession Q9P0M9, 148 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.
- UniProt accession: Q9P0M9; gene symbol MRPL27.
- Organism: Homo sapiens.
- Length: 148 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, skin pigmentation and systemic juvenile idiopathic arthritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large ribosomal subunit protein bL27m |
|---|---|
| UniProt accession | Q9P0M9 |
| Gene | MRPL27 |
| Organism | Homo sapiens |
| Length | 148 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (8)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- skin pigmentation · score 0.02
- systemic juvenile idiopathic arthritis · score 0.02
- lung adenocarcinoma · score 0.01
- squamous cell carcinoma · score 0.01
- Alzheimer disease · score 0.00
- colorectal cancer · score 0.00
- pancreatic ductal adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0M9-F1 | alphafold | PREDICTED | 86.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0M9.
Amino-acid sequence (148 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRPL27?
The strongest Open Targets associations for MRPL27 are neurodegenerative disease, skin pigmentation, systemic juvenile idiopathic arthritis, lung adenocarcinoma and squamous cell carcinoma.
How long is the MRPL27 protein?
The Homo sapiens MRPL27 protein (UniProt Q9P0M9) is 148 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0M9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0M9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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