Transmembrane protein 216 (TMEM216)
Homo sapiens — UniProt Q9P0N5
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 216 (TMEM216) is a protein from Homo sapiens identified by UniProt accession Q9P0N5, 145 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q9P0N5; gene symbol TMEM216.
- Organism: Homo sapiens.
- Length: 145 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, Meckel syndrome and Joubert syndrome with oculorenal defect.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 216 |
|---|---|
| UniProt accession | Q9P0N5 |
| Gene | TMEM216 |
| Organism | Homo sapiens |
| Length | 145 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.77
- Meckel syndrome · score 0.73
- Joubert syndrome with oculorenal defect · score 0.62
- genetic disorder · score 0.44
- orofaciodigital syndrome type 6 · score 0.37
- Abnormality of the nervous system · score 0.27
- refractive error measurement · score 0.14
- Microcephaly · score 0.11
- body height · score 0.07
- Jeune syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0N5-F1 | alphafold | PREDICTED | 89.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0N5.
Amino-acid sequence (145 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM216?
The strongest Open Targets associations for TMEM216 are Joubert syndrome, Meckel syndrome, Joubert syndrome with oculorenal defect, genetic disorder and orofaciodigital syndrome type 6.
How long is the TMEM216 protein?
The Homo sapiens TMEM216 protein (UniProt Q9P0N5) is 145 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0N5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0N5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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